The Pandemic Fueled a Superbug Surge. Can Medicine Recover?

The Pandemic Fueled a Superbug Surge. Can Medicine Recover?

the desperate need to save the lives of Covid patients during the first waves of the pandemic, coupled with shortages of hospital staff and protective equipment, caused a shocking turnaround against deadly superbugs, according to a new analysis from the U.S. Centers for Disease Control and Prevention . The report, released on July 12, synthesizes … Read more

How should we react to the global monkeypox outbreak?

Study: Unusual global outbreak of monkeypox: what should we do? Image Credit: Marina Demidiuk/Shutterstock

In a recent study published in the Limits of Medicine magazine, researchers have assessed various aspects of the global monkeypox outbreak. Study: Unusual Global Monkeypox Outbreak: What Should We Do? Image Credit: Marina Demidiuk/Shutterstock In recent times, monkeypox infections have become a topic of global concern amid the ongoing 2019 coronavirus disease (COVID-19) pandemic. Monkeypox … Read more

Remdesivir activates urotensin II receptor and induces cardiomyocyte dysfunction

Study: Activation of the urotensin-II receptor by anti-COVID-19 drug remdesivir induces cardiomyocyte dysfunction. Image Credit: felipe caparros/Shutterstock

In a recent study posted to the bioRxiv* preprint server, researchers assessed the cardiac effects of remdesivir. Study: Activation of the urotensin II receptor by remdesivir against the COVID-19 drug induces dysfunction of cardiomyocytes. Image credit: felipe caparros/Shutterstock Background Nucleoside analogues have long been used to design antiviral drugs. Nucleoside analogs inhibit viral RNA-dependent RNA … Read more

Mechanistic insights into engineered ACE2 receptor traps

Study: Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Image Credit: Kateryna Kon/Shutterstock

In a recent study posted on bioRxiv*, researchers have determined the cryoelectron microscopic (cryo-EM) structures of engineered angiotensin-converting enzyme 2 (ACE2) receptor traps. Study: Computational pipeline provides mechanistic understanding of Omicron variant of care neutralizing engineered ACE2 receptor traps. Image Credit: Kateryna Kon/Shutterstock Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has acquired multiple mutations during … Read more

Study identifies multiple pathways adopted by SARS-CoV-2 to develop resistance to nirmatrelvir

Study: Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir. Image Credit: Sutthituch/Shutterstock

In a recent study posted to the bioRxiv* pre-print server, researchers have identified multiple pathways that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could take to develop high resistance to nirmatrelvir, an oral antiviral that targets the 3C-like protease ( 3CLpro) of SARS-CoV-2. Study: Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir. Image Credit: Sutthituch/Shutterstock Background … Read more

Norwegian Cruise’s News Bodes Well for Carnival, Royal Caribbean

Norwegian Cruise's News Bodes Well for Carnival, Royal Caribbean

Norwegian Cruise Line (NCLH) – Report from Norwegian Cruise Line Holdings Ltd. to acquire dropped mandatory covid vaccinations on sailings from US ports, making it the first major cruise line to do so. In theory that should bring more passengers on board and maybe win a former Royal Caribbean International (RCL) – Get Royal Caribbean … Read more

SARS-CoV-2 receptor-binding domain-based protein subunit vaccine shows promise against multiple SARS-CoV-2 variants

Study: Broad immunity to SARS-CoV-2 variants of concern mediated by a SARS-CoV-2 receptor-binding domain protein vaccine. Image Credit: PIC SNIPE/Shutterstock

In a recent study posted to the medRxiv* pre-print server, researchers described a novel protein subunit vaccine comprising the receptor binding domain (RBD) of ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein dimerized with an immunoglobulin (Ig) G1 fraction, crystallizable (Fc) domain. Study: Broad immunity to SARS-CoV-2 variants of concern mediated by … Read more

UIC focuses on developing an antiviral therapy for filoviruses

UIC focuses on developing an antiviral therapy for filoviruses

Researchers from the University of Illinois Chicago are teaming up with the National Institutes of Health and researchers from around the country to establish a center to develop antiviral drugs for pandemic viruses, including Ebola and SARS-CoV-2, the virus. that COVID-19. The center, called the Midwest Antiviral Drug Discovery Center, is led by the University … Read more

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

UTSW scientists discover mechanism of RNA capping by SARS-CoV-2 virus

A team led by UT Southwestern researchers has determined how SARS-CoV-2, the virus that causes COVID-19, builds a structure called the RNA cap, which is critical to successful viral replication. The finding, published in Naturecould lead to new strategies to attack COVID-19, which has so far sickened nearly 600 million people and killed more than … Read more

Review of natural products with promising anti-SARS-CoV-2 potential

Study: Promising natural products against SARS-CoV-2: Structure, function, and clinical trials. Image Credit: Olga Larionova/Shutterstock

In a recent review published in Research into phytotherapyresearchers examined existing literature on naturally active products with therapeutic efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Promising Natural Products Against SARS-CoV-2: Structure, Function and Clinical Trials. Image Credit: Olga Larionova/Shutterstock Studies have reported breakthrough infections from coronavirus disease 2019 (COVID-19) and multiple mutations … Read more