Patrick Dorgu and Ayden Heaven are available to make their Manchester United debuts against Leicester City in the FA Cup fourth round on Friday.
Dorgu, 20, joined United from Lecce last week for a fee rising to £29million while the 18-year-old Heaven arrived from Arsenal for an undisclosed compensation fee.
"We’ll see," United head coach Ruben Amorim replied when asked if the duo could be involved. "You guys have to wait until tomorrow but they are ready to play and are two more solutions in this moment."
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Lisandro Martinez has been ruled out for at least the remainder of the season with a cruciate ligament injury sustained in the second half of the 2-0 defeat to Crystal Palace on Sunday.
Heaven is a fellow left-footed centre back but left back Luke Shaw, who has also played on the left of a back three, has suffered a setback in his recovery from a hamstring injury.
Shaw, 29, resumed full training last week but will not feature against Leicester. Amorim admitted the club have to be careful with a player who last started for United on February 18 last year.
"Licha is a difficult situation," Amorim added. "He’s going to be out for a while. We don’t know the extent of the injury but it’s going to take time.
"Luke has one small issue in the difficult area from the last injury, so we try to be careful with Luke."
Mason Mount and Jonny Evans are still out with muscle injuries.
